Enzymatic processes for L-phenylalanine production.
نویسندگان
چکیده
منابع مشابه
Dual enzymatic routes to L-tyrosine and L-phenylalanine via pretyrosine in Pseudomonas aeruginosa.
Pretyrosine, an intermediate of L-tyrosine biosynthesis in blue-green algae, was found to be enzymatically formed and utilized in Pseudomonas aeruginosa. The enzymology and regulation of aromatic biosynthesis were re-evaluated in the context of these new findings, Four species of aromatic aminotranaferase were separated and partially purified. Each was reactive with prephenate, phenylpyruvate, ...
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Phenylketonuria (PKU) is one of the most prevalent types of hereditary metabolic disorders which is caused due to an absence or reduction of the activity of the Phenylalanine hydroxylase enzyme in the liver which in turn, inhibits the transformation of phenylalanine (Phe) to tyrosine. In clinical terms, this disorder is displayed with severe, permanent and irreversible mental retardation. This ...
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-Tyrosinase, tryptophanase and cysteine desulfhydrase were shown to catalyze a variety of a,—elimination, s—replacement and the reverse of the ct,—elimination reactions of amino acids. The mechanism f or these reactions was studied using the general mechanism for pyridoxal— dependent reactions. The enzyme—bound n—amino acrylate is the key intermediate. Enzymatic methods for preparing L—tyrosine...
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Phenylketonuria (PKU) is an autosomal recessive disorder, which is characterized by severe mental retardation, microcephaly and seizures. The symptoms of this disease can be prevented if detected soon after birth. Therefore, blood Phenylalanine (Phe) measurement is essential for the early diagnosis, treatment and dietary monitoring of PKU patients. The goal of this research was to introduce a r...
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BACKGROUND L-phenylalanine (L-Phe) is an essential amino acid for mammals and applications expand into human health and nutritional products. In this study, a system level engineering was conducted to enhance L-Phe biosynthesis in Escherichia coli. RESULTS We inactivated the PTS system and recruited glucose uptake via combinatorial modulation of galP and glk to increase PEP supply in the Xllp...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1988
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.46.160